Exercising heart failure patients: cardiac protection through preservation of mitochondrial function and substrate utilization?

• DOI: 10.1016/j.cophys.2023.100656
• Publication Date: 2023-03-17T16:25:27Z
• Authors: Kirsten T Nijholt; Suzanne N Voorrips; Pablo I Sánchez-A...; Berend Daan Weste...

Current heart failure (HF) therapy remains unable to substantially improve exercise capacity. Studies have shown that training has beneficial effects on the in both health and disease. How mitochondria respond this setting has, however, received less attention literature. These may include protective changes mitochondrial function adaptations substrate utilization. This review describes exercise-induced cardiac metabolism, including utilization their function. We conclude exercising HF patients can optimize utilization, eventually improving or restoring suggests itself should be incorporated treatment plan, term Extending knowledge mechanisms by which exerts could potentially lead development of therapies directed at HF.