Decreased transfer of value to action in Tourette syndrome

• DOI: 10.1016/j.cortex.2019.12.027
• Publication Date: 2020-01-24T19:20:21Z
• Authors: Thomas Schüller; Adrian G. Fischer; Theo O.J. Gruendler; Juan Carlos Balde...; Daniel Huys; Markus Ullsperger; Jens Kuhn
• Keywords: 0301 basic medicine; 03 medical and health sciences; Reward; Action, intention, and motor control; Dopamine; Humans; Learning; Reinforcement, Psychology; Tourette Syndrome

Tourette syndrome is a neurodevelopmental disorder putatively associated with a hyperdopaminergic state. Therefore, it seems plausible that excessive dopamine transmission in Tourette syndrome alters the ability to learn based on rewards and punishments. We tested whether Tourette syndrome patients exhibited altered reinforcement learning and corresponding feedback-related EEG deflections.We used a reinforcement learning task providing factual and counterfactual feedback in a sample of 15 Tourette syndrome patients and matched healthy controls whilst recording EEG. The paradigm presented various reward probabilities to enforce adaptive adjustments. We employed a computational model to derive estimates of the prediction error, which we used for single-trial regression analysis of the EEG data.We found that Tourette syndrome patients showed increased choice stochasticity compared to controls. The feedback-related negativity represented an axiomatic prediction error for factual feedback and did not differ between groups. We observed attenuated P3a modulation specifically for factual feedback in Tourette syndrome patients, representing impaired coding of attention allocation.Our findings indicate that cortical prediction error coding is unaffected by Tourette syndrome. Nonetheless, the transfer of learned values into choice formation is degraded, in line with a hyperdopaminergic state.