Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis

• DOI: 10.1016/j.csbj.2021.01.012
• Publication Date: 2021-01-18T07:25:26Z
• Authors: Hung-Jin Huang; Margarita Chetyrkina; Chui-Wei Wong; Olga A. Kraevaya; Alexander V. Zhil...; Ilya I. Voronov; Pei-Hwa Wang; Pavel A. Troshin; Shan-hui Hsu
• Keywords: Identification

Water-soluble fullerene derivatives are actively investigated as potential drugs for cancer treatment due to their favorable membranotropic properties. Herein, cytotoxic effects of twenty with different solubilizing addends were evaluated in three types non-small-cell lung carcinoma (NSCLC). The structural descriptors the related inhibitory activities on each type cell by quantitative structure-activity relationship (QSAR) approach. determination coefficient