Stem Cell–based Therapies for Bone Repair

• DOI: 10.1016/j.cveq.2011.05.002
• Publication Date: 2011-08-27T14:13:07Z
• Authors: Peter I. Milner; Peter D. Clegg; Matthew C. Stewart
• Keywords: Fracture Healing; 0301 basic medicine; Fractures, Bone; 0303 health sciences; 03 medical and health sciences; Osteogenesis; Animals; Horse Diseases; Mesenchymal Stem Cells; Horses; Stem Cell Transplantation

This article provides an overview of the cellular and molecular events involved in bone repair and the current approaches to using stem cells as an adjunct to this process. The article emphasizes the key role of osteoprogenitor cells in the formation of bone and where the clinical applications of current research may lend themselves to large animal orthopaedics. The processes involved in osteogenic differentiation are presented and strategies for bone formation, including induction by osteogenic factors, bioscaffolds, and gene therapy, are reviewed.