Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis
0301 basic medicine
Chromatin Immunoprecipitation
Binding Sites
Light
Arabidopsis Proteins
Arabidopsis
Nuclear Proteins
Plants, Genetically Modified
DNA-Binding Proteins
03 medical and health sciences
Plant Growth Regulators
Gene Expression Regulation, Plant
Gene Regulatory Networks
Steroids
Genome, Plant
Developmental Biology
Oligonucleotide Array Sequence Analysis
Signal Transduction
Transcription Factors
DOI:
10.1016/j.devcel.2010.10.010
Publication Date:
2010-11-16T09:10:47Z
AUTHORS (16)
ABSTRACT
Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.
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