Golgin160 Recruits the Dynein Motor to Position the Golgi Apparatus

• DOI: 10.1016/j.devcel.2012.05.023
• Publication Date: 2012-07-16T15:33:52Z
• Authors: Smita Yadav; Manojkumar A. Put...; Adam D. Linstedt
• Keywords: Organelle

Membrane motility is a fundamental characteristic of all eukaryotic cells. One the best-known examples that mammalian Golgi apparatus, where constant inward movement membranes results in its position near centrosome. While it clear minus-end-directed motor dynein required for this process, mechanism and regulation recruitment to remains unknown. Here, we show protein golgin160 recruits membranes. This confers centripetal regulated by GTPase Arf1. Further, during cell division, association with dissociation receptor-motor complex from These identify cell-cycle-regulated membrane receptor molecular suggest mechanistic basis achieving dramatic changes organelle positioning seen division.