Tissue-Specific Regulation of Gibberellin Signaling Fine-Tunes Arabidopsis Iron-Deficiency Responses

• DOI: 10.1016/j.devcel.2016.03.022
• Publication Date: 2016-04-21T15:45:51Z
• Authors: Michael Wild; Jean-Michel Davière; Thomas Regnault; Lali Sakvarelidze...; Esther Carrera; Isabel Lopez Diaz; Anne Cayrel; Guillaume Dubeaux; Grégory Vert; Patrick Achard
• Keywords: 2. Zero hunger; 0301 basic medicine; 0303 health sciences; Arabidopsis thaliana; Arabidopsis Proteins; Iron deficiency; Iron; Arabidopsis; FIT; [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology; Plant Roots; Gibberellins; 03 medical and health sciences; Root epidermis; Plant Growth Regulators; Gene Expression Regulation, Plant; Basic Helix-Loop-Helix Transcription Factors; DELLA; [SDV.BC] Life Sciences [q-bio]/Cellular Biology

Iron is an essential element for most living organisms. Plants acquire iron from the rhizosphere and have evolved different biochemical and developmental responses to adapt to a low-iron environment. In Arabidopsis, FIT encodes a basic helix-loop-helix transcription factor that activates the expression of iron-uptake genes in root epidermis upon iron deficiency. Here, we report that the gibberellin (GA)-signaling DELLA repressors contribute substantially in the adaptive responses to iron-deficient conditions. When iron availability decreases, DELLAs accumulate in the root meristem, thereby restraining root growth, while being progressively excluded from epidermal cells in the root differentiation zone. Such DELLA exclusion from the site of iron acquisition relieves FIT from DELLA-dependent inhibition and therefore promotes iron uptake. Consistent with this mechanism, expression of a non-GA-degradable DELLA mutant protein in root epidermis interferes with iron acquisition. Hence, spatial distribution of DELLAs in roots is essential to fine-tune the adaptive responses to iron availability.