Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss

• DOI: 10.1016/j.devcel.2020.03.019
• Publication Date: 2020-04-20T15:16:52Z
• Authors: Wisoo Shin; Nicole L. Rosin; Holly Sparks; Sarthak Sinha; Waleed Rahmani; Nilesh Sharma; Matt Workentine; Sepideh Abbasi; Elodie Labit; Jo Anne Stratton; Jeff Biernaskie
• Keywords: Mesenchyme; Progenitor

Highlights•In vivo ablation of anagen DP cells initiates activation and repopulation by hfDSCs•Single-cell RNA-seq reveals dysfunction aged HF mesenchyme progressive loss•hfDSCs are seconded to replenish the in HFs•Aging causes hfDSC depletion progenitor poolSummarySkin aging is accompanied hair loss due impairments follicle (HF) epithelial their mesenchymal niche. This inductive mesenchyme, called dermal papilla (DP), undergoes cell eventual miniaturization that contributes pathogenesis. Using laser fate mapping, we show stem (hfDSCs) reconstitute damaged maintain growth, suggesting may trigger degeneration Fate mapping over 24 months revealed depletion, clonal analysis hfDSCs showed impaired self-renewal biased differentiation. Single-cell confirmed as a central precursor, giving rise divergent trajectories. In skin, exhibited senescent-like characteristics, senescence-associated secretory phenotypes were identified mesenchyme. These results clarify fibroblast dynamics within suggest pool age-related loss.Graphical abstract