Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6

• DOI: 10.1016/j.diagmicrobio.2011.09.019
• Publication Date: 2011-11-11T19:08:58Z
• Authors: Norifumi Shigemoto; Ryuichi Kuwahara; Shizuo Kayama; Wataru Shimizu; Makoto Onodera; Michiya Yokozaki; Junzo Hisatsune; Fuminori Kato; Hiroki Ohge; Motoyuki Sugai
• Keywords: Klebsiella; Carbapenem

We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.