Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital

• DOI: 10.1016/j.diagmicrobio.2015.10.009
• Publication Date: 2015-10-25T18:02:49Z
• Authors: Min Shen; Guangxin Luan; Yanhong Wang; Yaowen Chang; Chi Zhang; Jingni Yang; Shanshan Deng; Baodong Ling; Xu Jia
• Keywords: Acinetobacter baumannii; Quinolone; Neisseriaceae

A total of 101 Acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. Among 77 quinolone-resistant A. baumannii harbored mutations of gyrA and parC, 41 isolates, which belonged to European clone II, had resistance to aminoglycosides and carbapenems due to the expression of armA and acquisition of blaOXA-23. Most of sequence type belonged to clonal complex 92. These results suggested hospital dissemination of multidrug-resistant A. baumannii carrying blaOXA-23, armA, and mutations of quinolone resistance-determining regions in western China.