The idiosyncratic drug-induced gene expression changes in HepG2 cells

0403 veterinary science Q1-390 Science (General) Computer applications to medicine. Medical informatics Journal Article R858-859.7 04 agricultural and veterinary sciences Pharmacology, Toxicology and Pharmaceutical Science 3. Good health
DOI: 10.1016/j.dib.2017.07.074 Publication Date: 2017-07-30T00:15:30Z
ABSTRACT
The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We exposed HepG2 cells with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, in the presence (I+ and N+) or absence (I- and N-) of a cytokine mix for 6, 12 and 24 h. To investigate the genome-wide expression patterns, microarray was performed using the Agilent 4×44K Whole Human Genome chips. The data presented in this DIB include the expression of genes participating in the ceramide metabolism, ER stress, apoptosis and cell survival pathways. The functions of these genes were illustrated in our associated article (Jiang et al., 2017) [1]. Raw and normalized gene expression data are available through NCBI GEO (accession number GSE102006).
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (2)
CITATIONS (2)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....