Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line

• DOI: 10.1016/j.dib.2017.10.033
• Publication Date: 2017-10-17T15:02:10Z
• Authors: A. Ardelt; R. Carpenter; I. Iwuchukwu; A. Zhang; W. Lin; E. Kosciuczuk; C. Hinkson; T. Rebeiz; S. Reitz; P. King
• Keywords: 0301 basic medicine; Q1-390; 03 medical and health sciences; Science (General); 0302 clinical medicine; Computer applications to medicine. Medical informatics; R858-859.7; Neuroscience

This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR. Additionally, the effect of cerebral ischemia on the expression of endogenous Hu proteins is presented.