Dataset on amelogenesis-related genes variants (ENAM and ENAM interacting genes) and on human leukocyte antigen alleles (DQ2 and DQ8) distribution in children with and without molar-incisor hypomineralisation (MIH)

• DOI: 10.1016/j.dib.2020.106224
• Publication Date: 2020-08-25T01:45:00Z
• Authors: Luka Hočevar; Jernej Kovač; Katarina Trebušak...; Saba Battelino; Alenka Pavlič
• Keywords: Housekeeping gene; Amelogenesis

All children, who were born in 2004 and had undergone surgical treatment for recurrent acute tonsillitis and/or otitis media at the ear, nose throat clinic (ENT) between 2010, called on dental examination blood sampling. Out of 441 invitees, 113 children their parents/legal guardians agreed to participate. The following data from this group subjects are presented: presence clinical signs molar-incisor hypomineralisation (MIH), distribution human leukocyte antigen (HLA) alleles DQ2 DQ8 eight single nucleotide polymorphisms (SNPs) located amelogenesis-related genes (rs3796704 ENAM gene, rs546778141 AMBN rs2106416 AMELX rs7660807 rs35286445 AMTN rs4870723 COL14A1 rs2245803 MMP20 rs3828054 TUFT1 gene). Data MIH collected accordance with recommendation proposed recording sheet [1], appropriate preliminary training calibration. HLA haplotypes SNPs obtained using DNA isolated samples taken subjects. determined EliGene® Coeliac RT Kits (90,048-RT; Elisabeth Pharmacon spol. s.r.o., Brno-Židenice, Czech Republic) a 7500 Fast RT-PCR System (Applied Biosystems, Waltham, MA, USA). distributions high resolution melting (HRM) Type-IT HRM Master Mix (Qiagen), TaqMan genotyping assays (ID: C__25766207_10; Thermo Fisher Scientific, USA) Universal II, or Sanger sequencing master mix BigDye® Terminator v3.1 Biosystems) ABI 3500 Genetic Analyser Biosystems). L. Hočevar, J. Kovač, K. Trebušak Podkrajšek, S. Battelino, A. Pavlič, 2020. possible influence genetic aetiological factors hypomineralisation, Arch. Oral. Biol. 118, 104848. https://doi.org/10.1016/j.archoralbio.2020.104848.