Proteomic dataset: Profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation

• DOI: 10.1016/j.dib.2021.107658
• Publication Date: 2021-12-01T17:26:00Z
• Authors: Artemiy S. Silantyev; Olga N. Bukato; Ivan O. Butenko; Anastasia A. Cher...; Olga V. Pobeguts; Alexander E. Nosyrev; Olga I. Gurina
• Keywords: Q1-390; 03 medical and health sciences; Science (General); 0302 clinical medicine; Proteome; Computer applications to medicine. Medical informatics; R858-859.7; Glioma C6; Co-culture; LC-MS/MS; Data Article

Human multiforme glioblastoma is characterized by an unfavorable prognosis, low survival rate and extremely limited possibilities for therapy. Rat C6 glioma is an experimental model for the study of glioblastoma growth and invasion. It has been shown that the growth and development of the tumor is accompanied by changes in the surrounding normotypic tissues [1]. These changes create a favorable environment for the development of the tumor and give it an evolutionary advantage [2]. Description of changes occurring in normotypic cells of the body upon their contact with tumor cells is of great interest. We have grown C6 glioma cells and rat astrocytes, as well as astrocyte cells co-cultured together with C6 glioma. We performed proteome-wide LC-MS analysis of these experimental groups. The data includes LC-MS/MS raw files and exported MaxQuant and ProteinPilot search results with fasta. Dataset published in the PRIDE repository project accession PXD026776.