Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids

• DOI: 10.1016/j.dib.2022.108506
• Publication Date: 2022-08-02T08:55:32Z
• Authors: Minsuh Kim; Ji Min Kim; Eun Jeong Cho; Chang Ohk Sung; Joon Kim; Se Jin Jang
• Keywords: Organoid; Arrestin

The data presented in this article is related to a rapid communication entitled "β-arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity". This describes correlation β-arrestin and phosphorylation patient-derived organoid models. Here, we analyzed 45 colon cancer organoids (CCOs) selected research investigate role phosphorylation. Hematoxylin eosin (H&E) staining immunohistochemistry showed that CCOs maintained tissue architecture histological features their original tissues. Moreover, mutation detected from RNA-seq (RNA-sequencing) analysis these retained genetic tissues as well. We also confirmed at protein level expressing high expression phosphorylated YAP. These model studies strongly support cancer.