Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation

• DOI: 10.1016/j.dib.2022.108770
• Publication Date: 2022-11-21T17:02:14Z
• Authors: Yingjuan Liu; Mun-kit Choy; Sabu Abraham; Gennadiy Tenin; Graeme C. Black; Bernard D. Keavney
• Keywords: Expression (computer science)

This article presents data concerning STX18-AS1, a long noncoding RNA gene identified from Genome-wide association study of Atrial Septal Defect (ASD). The describes its expression patterns in human tissues and functions regulating cardiomyocyte differentiation vitro. STX18-AS1 is lncRNA with higher abundance developing tissues, including hearts. Its transcription distribution within the embryonic hearts during key heart septation stages supports STX18-AS1's risk SNPs for ASD. CRISPR stem cell pool which was knocked down, showed reduced CM efficiency lower cardiac transcriptional factors. indicated regulative role supporting lineage specification mesoderm into progenitors cardiomyocytes. These can benefit understanding developmental biology, time-course changes factors vitro cells.