Genetic and non-genetic risk factors for early-onset pancreatic cancer

• DOI: 10.1016/j.dld.2023.02.023
• Publication Date: 2023-03-25T20:13:55Z
• Authors: Ylenia Nodari; Manuel Gentiluomo; Beatrice Mohelnik...; Edita Kreivenaite; Anna Caterina Mil...; Jurgita Skiecevic...; Stefano Landi; Rita T Lawlor; Maria Chiara Petrone; Paolo Giorgio Arc...; Martin Lovecek; Maria Gazouli; Maarten F. Bijlsma; Luca Morelli; Vytautas Kiudelis; Matteo Tacelli; Dalila Lucíola Za...; Pavel Soucek; Faik Uzunoglu; Rudolf Kaaks; Jakob Izbicki; Ugo Boggi; Raffaele Pezzilli; Andrea Mambrini; Claudio Pasquali; Hanneke W. van La...; Verena Katzke; Giulia Martina Ca...; Cosimo Sperti; Martin Loos; Anna Latiano; Bálint Erőss; Martin Oliverius; Theron Johnson; Daniela Basso; John P. Neoptolemos; Mateus Nóbrega Aoki; William Greenhalf; Pavel Vodicka; Livia Archibugi; Giuseppe Vanella; Maurizio Lucchesi; Renata Talar-Wojn...; Krzysztof Jamroziak; Mohammed Al Saeedi; Casper H.J. van E...; Juozas Kupcinskas; Tamás Hussein; Marta Puzzono; Stefania Bunduc; Mara Götz; Silvia Carrara; Andrea Szentesi; Francesca Tavano; Stefania Moz; Péter Hegyi; Claudio Luchini; Gabriele Capurso; Francesco Perri; Stefano Ermini; George Theodoropo...; Giovanni Capretti; Orazio Palmieri; Laura Ginocchi; Niccolò Furbetta; Federico Canzian; Daniele Campa
• Keywords: Etiology; Genome-wide Association Study

Early-onset pancreatic cancer (EOPC) represents 5-10% of all ductal adenocarcinoma (PDAC) cases, and the etiology this form is poorly understood. It not clear if established PDAC risk factors have same relevance for younger patients. This study aims to identify genetic non-genetic specific EOPC.A genome-wide association was performed, analysing 912 EOPC cases 10 222 controls, divided into discovery replication phases. Furthermore, associations between a polygenic score (PRS), smoking, alcohol consumption, type 2 diabetes were also assessed.Six novel SNPs associated with in phase, but phase. The PRS, affected risk. OR comparing current smokers never-smokers 2.92 (95% CI 1.69-5.04, P = 1.44 × 10-4). For diabetes, corresponding 14.95 3.41-65.50, 3.58 10-4).In conclusion, we did variants specifically EOPC, found that do strong age-dependent effect. add evidence pointing role smoking EOPC.