Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers

• DOI: 10.1016/j.drup.2023.101042
• Publication Date: 2024-01-04T08:54:10Z
• Authors: Yuanfang Li; Baiwei Zhao; Juzheng Peng; Hailin Tang; Sicheng Wang; Sicheng Peng; Feng Ye; Junye Wang; Kai Ouyang; Jianjun Li; Manbo Cai; Yongming Chen

Drug resistance in cancer remains a major challenge oncology, impeding the effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling pathway has emerged as critical player development drug cells. This comprehensive review explores intricate relationship between NF-κB and cancer. We delve into molecular mechanisms through which activation contributes to against chemotherapeutic agents, targeted therapies, immunotherapies. Additionally, we discuss potential strategies overcome this by targeting signaling, such small molecule inhibitors combination therapies. Understanding multifaceted interactions is crucial for more effective strategies. By dissecting complex network NF-κB, hope shed light on novel therapeutic approaches that can enhance outcomes, ultimately improving prognosis patients. aims provide overview current state knowledge its role resistance, offering insights may guide future research interventions fight