Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

• DOI: 10.1016/j.drup.2024.101172
• Publication Date: 2024-11-13T13:36:21Z
• Authors: Pei-Yao Zhai; Zhi-Xian Chen; Ting Jiang; Jian Feng; Bin Zhang; Xiao Zang; Yan-Lin Zhao; Gang Qin
• Keywords: Drug resistant tuberculosis

This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need second-line treatment, offering promising approach mitigate DR-TB burden by 2050.