Synthesis and application of clickable and biocompatible fluorescent glycosyl labels

• DOI: 10.1016/j.dyepig.2014.09.037
• Publication Date: 2014-10-09T18:52:42Z
• Authors: Zhiwei Lei; Jie Wang; Yuxin Tian; Gaopeng Song; Gang Zhao; Hanhong Xu
• Keywords: Biomolecule; Biocompatible material; Conjugate; Bioorthogonal Chemistry

Two novel, biocompatible and highly stereoselective fluorescent glycosyl labels featuring azide groups have been successfully synthesized. The functional groups provide convenient routes for fluorescent glycosyl conjugates via click chemistry. Three fluorescent glycose-conjugates were synthesized. One fluorescent conjugate was used to trace the translocation in castor seedlings. The developed fluorescent labels for biomolecules are likely to provide an important method for investigating various biological events. We believe that the probes obtained are useful for studies on biological processes.