Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates

• DOI: 10.1016/j.ebiom.2021.103695
• Publication Date: 2021-11-11T12:38:10Z
• Authors: Mira Mousa; Hema Vurivi; Hussein Kannout; Maimunah Uddin; Nawal Alkaabi; Bassam Mahboub; Guan K. Tay; Habiba S Alsafar
• Keywords: Genome-wide Association Study; Genetic Association; SNP

The heterogeneity in symptomatology and phenotypic profile attributable to COVID-19 is widely unknown. objective of this manuscript conduct a trans-ancestry genome wide association study (GWAS) meta-analysis severity improve the understanding potentially causal targets for SARS-CoV-2.This cross-sectional recruited 646 participants UAE that were divided into two groups based on phenotypes, hospitalized (n=482) non-hospitalized (n=164) participants. Hospitalized patients developed acute respiratory distress syndrome (ARDS), pneumonia or progression failure required supplemental oxygen therapy mechanical ventilation support had severe complications such as septic shock multi-organ failure. We conducted GWAS European (n=302), American (n=102), South Asian (n=99), East (n=107) ancestry populations. also carried out comprehensive post-GWAS analysis, including enrichment SNP associations tissues cell-types, expression quantitative trait loci differential analysis.Eight genes demonstrated strong signal: VWA8 gene locus 13p14·11 (SNP rs10507497; p=9·54 x10-7), PDE8B 5q13·3 rs7715119; p=2·19 x10-6), CTSC 11q14·2 (rs72953026; p=2·38 THSD7B 2q22·1 (rs7605851; p=3·07x10-6), STK39 2q24·3 (rs7595310; p=4·55 FBXO34 14q22·3 (rs10140801; p=8·26 RPL6P27 18p11·31 (rs11659676; p=8·88 METTL21C 13q33·1 (rs599976; p=8·95 x10-6). are expressed lung, associated tumour progression, emphysema, airway obstruction, surface tension within well an T-cell-mediated inflammation production inflammatory cytokines.We have discovered eight highly plausible genetic with cases COVID-19. Further studies must be worldwide population genetics facilitate development specific therapeutics mitigate challenge.This review was commissioned part project host cell receptors coronaviruses funded by Khalifa University's CPRA grant (Reference number 2020-004).