Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

• DOI: 10.1016/j.ebiom.2021.103723
• Publication Date: 2021-11-27T05:09:15Z
• Authors: Wen Zhong; Ozlem Altay; Muhammad Arif; Fredrik Edfors; Levent Doganay; Adil Mardinoglu; Mathias Uhlen; Linn Fagerberg
• Keywords: Proteome

COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying various effects disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis plasma protein profiles using proximity extension assays combined with next generation sequencing been developed, which allows multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity.We patients (n = 50) mild and moderate symptoms by comparing levels in newly diagnosed same individuals after 14 days.The study identified more than 200 that are significantly elevated during infection many these related cytokine response other immune-related functions. In addition, several shown elevated, including SCARB2, host cell receptor involved virus entry. A comparison severe shows highly similar pattern, but some interesting differences.The presented here demonstrates usefulness "next profiling" identify molecular signatures importance progression allow monitoring recovery from infection. The results will facilitate further studies understand mechanism SARS-CoV-2 virus.This work was financially supported Knut Alice Wallenberg Foundation.