Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

• DOI: 10.1016/j.ebiom.2023.104620
• Publication Date: 2023-05-22T18:26:36Z
• Authors: Nicholas Darci-Maher; Marcus Alvarez; Uma Thanigai Arasu; Ilakya Selvarajan; Seung Hyuk T. Lee; David Z. Pan; Zong Miao; Sankha Subhra Das; Dorota Kaminska; Tiit Örd; Jihane N. Benhammou; Martin Wabitsch; Joseph R. Pisegna; Ville Männistö; Kirsi H. Pietiläinen; Markku Laakso; Janet S. Sinsheimer; Minna U. Kaikkonen; Jussi Pihlajamäki; Päivi Pajukanta
• Keywords: Steatosis

Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic accumulation into the liver.