The effects of TPT and dietary quercetin on growth, hepatic oxidative damage and apoptosis in zebrafish

• DOI: 10.1016/j.ecoenv.2021.112697
• Publication Date: 2021-08-25T00:36:00Z
• Authors: Chunnuan Zhang; Dongxue Jiang; Junhui Wang; Qian Qi
• Keywords: Malondialdehyde

The objective of this study was to determine the effects triphenyltin (TPT) and dietary quercetin on growth, oxidative stress apoptosis in zebrafish. A total 240 fish were divided into 4 groups with three replicates as follows: fed basal diet control group (D1), only 10 ng/L TPT (D2), + 100 mg/kg (D3), mg/Kg D4 group. At end period (56 d), results showed that growth performance significantly higher than exposed TPT. Quercetin ameliorated stress, which decreased malondialdehyde (MDA) nitric oxide (NO) levels improved antioxidant enzyme activities. mRNA expressions key apoptotic gene pro-inflammatory cytokines induced by exposure. However, prevented a marked increase Bax, caspase3 caspase9 transcript abundances In addition, treatments inflammation regulating NF-kB signalling pathway. conclusion, our findings suggested zebrafish pretreatment an ameliorative role. Dietary mg/ kg helps prevent damage, treated