The effects of TPT and dietary quercetin on growth, hepatic oxidative damage and apoptosis in zebrafish
Inflammation
Environmental sciences
0301 basic medicine
0303 health sciences
03 medical and health sciences
TD172-193.5
Oxidative stress
Triphenyltin
Quercetin
Apoptosis
GE1-350
Environmental pollution
DOI:
10.1016/j.ecoenv.2021.112697
Publication Date:
2021-08-25T00:36:00Z
AUTHORS (4)
ABSTRACT
The objective of this study was to determine the effects of triphenyltin (TPT) and dietary quercetin on the growth, oxidative stress and apoptosis in zebrafish. A total of 240 fish were divided into 4 groups with three replicates as follows: fish were fed with the basal diet as the control group (D1), only 10 ng/L TPT (D2), 10 ng/L TPT + 100 mg/kg quercetin (D3), and only 100 mg/Kg quercetin as the D4 group. At the end of the study period (56 d), the results showed that the growth performance of the fish that were fed 100 mg/kg quercetin was significantly higher than that of fish that were exposed to 10 ng/L TPT. Quercetin ameliorated oxidative stress, which decreased malondialdehyde (MDA) and nitric oxide (NO) levels and improved antioxidant enzyme activities. The mRNA expressions of the key apoptotic gene and pro-inflammatory cytokines were significantly induced by TPT exposure. However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT. In addition, the quercetin treatments decreased inflammation by regulating the NF-kB signalling pathway. In conclusion, our findings suggested that TPT induced oxidative stress and apoptosis in zebrafish and that the pretreatment with quercetin showed an ameliorative role. Dietary 100 mg/ kg quercetin helps to prevent oxidative damage, apoptosis and inflammation in TPT treated zebrafish.
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