Long-term exposure to air pollution at residential and workplace addresses and breast cancer risk: A case-control study nested in the French E3N-Générations cohort from 1990 to 2011

• DOI: 10.1016/j.ejca.2024.114293
• Publication Date: 2024-08-23T02:41:58Z
• Authors: Margaux Duboeuf; Amina Amadou; Thomas Coudon; Lény Grassot; Marie Ramel-Delobel; Elodie Faure; Pietro Salizzoni; John Gulliver; Gianluca Severi; Francesca Romana ...; Béatrice Fervers; Delphine Praud
• Keywords: Adult; Time Factors; Nitrogen Dioxide; Air pollution; Workplace history; [SDV.CAN]Life Sciences [q-bio]/Cancer; Breast Neoplasms; Breast cancer; Risk Factors; Air Pollution; Humans; Prospective Studies; Workplace; Nitrogen dioxide; Aged; [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health; Air Pollutants; Particulate matters; Residential history; Case-control study; Environmental Exposure; Middle Aged; Case-Control Studies; Land use regression; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Female; Particulate Matter; France

An increasing evidence links air pollution to breast cancer (BC) risk. Yet, pollutant exposure estimates at the workplace location in pollution exposure assessment have not been considered.This study investigates the association between particulate matters (PM2·5, PM10) and nitrogen dioxide (NO2) atmospheric concentrations (1990-2011), at the women's residential and workplace locations, and BC risk.This case-control study of 2419 BC cases and 2984 controls, was nested in the French prospective E3N cohort. The annual mean PM2·5, PM10 and NO2 concentrations were estimated using a Land Use Regression model (50 m x 50 m resolution) and assigned to the women's geocoded residential and workplace locations, from cohort recruitment to their index date (date of case diagnosis). Odds ratios (OR) and 95 % confidence intervals (CI) were estimated using multivariate logistic regression models.An increased BC risk was observed for a 10 µg/m3 increase of the 1990-2011 average PM2·5 concentration estimates (OR=1·28; CI 1·00, 1·63). An increased risk was suggested for a 10 µg/m3 increase for PM10 (OR=1·09; CI 0·92, 1·30) and NO2 (OR=1·05; CI 0·97, 1·13). No effect modification by menopausal status, nor difference by hormone receptor status were observed.This study is the first to estimate BC risk and long-term air pollutant exposure from both, residential and workplace location histories. Results suggest that residential PM2·5, PM10 and NO2 concentrations are strongly correlated with workplace ones, indicating that residential data may serve as proxy for overall exposure. Future studies should consider exposure during commuting.