Diagnostic MRI characteristics of pediatric clear cell sarcoma of the kidney and rhabdoid tumor of the kidney: A retrospective multi-center SIOP-RTSG Radiology panel study
Wilms tumor
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Pediatrics
03 medical and health sciences
Magnetic resonance imaging
0302 clinical medicine
Oncology
Dentistry (miscellaneous)
Rhabdoid tumor
Kidney neoplasms
Radiology
Clear cell sarcoma
RC254-282
DOI:
10.1016/j.ejcped.2023.100122
Publication Date:
2023-11-04T03:55:51Z
AUTHORS (14)
ABSTRACT
IntroductionClear cell sarcoma of the kidney (CCSK) and rhabdoid tumor (RTK) are rare malignant pediatric renal tumors, both accounting for 1-5% diagnoses. Within International Society Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) protocols diagnostic invasive procedures to determine histology discouraged. MRI has become preferred imaging modality, however, non-invasive discrimination CCSK RTK remains challenging. Therefore, this study aims identify MRI-characteristics RTK, in largest series patients date.Material MethodsFive SIOP-RTSG national review radiologists identified MRIs histologically proven CCSKs RTKs. Scan-protocols were based on MRI-guidelines following protocols. Radiologists assessed their cases using a validated case report form (CRF).ResultsRetrospectively, 59 (n=38 CCSK, n=21 RTK). showed high median volume (576 cm3, range 54-4414), which was lower RTKs (290 20-761) (p=0.006*10-3). Fifty-two percent (11/21) RTK-patients disease at other locations, predominantly lungs brain, compared 8% CCSK-patients (3/38). ill-defined margins (12/21, 57%) infiltrative growth pattern (13/21, 62%). appeared hyper-intense T2-weighted (27/38, 71%) with characteristics band-like enhancement (13/38, 34%), whereas often hypo-intensity (11/21, 52%). The overall mean ADC-value 1.11*10-3mm2/s (range 0.57-2.07*10-3 mm2/s), 0.72*10-3mm2/s 0.53-0.90*10-3 mm2/s) RTK.ConclusionsThis retrospective suggests small size, an aggressive may be characteristic RTK. typical relatively ADC-values. Identified used future studies focusing validation from especially WT, aiming early diagnosis.
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