Intrapleural intercostal nerve block associated with mini-thoracotomy improves pain control after major lung resection☆

• DOI: 10.1016/j.ejcts.2006.01.002
• Publication Date: 2006-02-15T12:21:06Z
• Authors: Antonio D’Andrilli; Mohsen Ibrahim; Anna Maria Ciccone; Federico Venuta; Tiziano De Giacomo; Domenico Massullo; Giovanni Pinto; Erino A. Rendina
• Keywords: Lung Diseases; Male; Pain, Postoperative; Lung Neoplasms; Nerve Block; Length of Stay; Middle Aged; 3. Good health; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Thoracotomy; Patient Satisfaction; Humans; Female; Intercostal Nerves; Pneumonectomy; intercostal nerve block; postoperative analgesia; mini-thoracotomy; major lung resection; Aged

To prospectively assess the impact of intrapleural intercostal nerve block (IINB) associated with mini-thoracotomy on postoperative pain and surgical outcome after major lung resections.Between January 2004 and February 2005, we randomly assigned 120 consecutive patients undergoing mini-thoracotomy (10-13 cm) for major lung resections, to receive or not IINB from the 4th to the 8th space at the moment of thoracotomy using 20 ml (7.5 mg/ml) ropivacain injection at the dose of 4 ml for each space. Postoperative analgesia consisted of continuous intravenous infusion of tramadol (10 mg/h) and ketoralac tromethamine (3 mg/h) for 48 h for all patients.The two groups (60 patients each) were comparable for age, sex, pulmonary function, type and duration of the procedure. Mortality and morbidity were 0% and 10%, respectively, for the IINB group and 3.3% and 15%, respectively, for the non-IINB group (p>0.05, NS). Mean postoperative pain measured by the 'Visual Analogue Scale' were as follows: 2.3+/-1 at 1 h, 2.2+/-0.8 at 12 h, 1.8+/-0.7 at 24 h, and 1.6+/-0.6 at 48 h for the IINB group; and 3.6+/-1.4 at 1 h, 3.4+/-2 at 12 h, 2.9+/-1.2 at 24 h, and 2.0+/-1 at 48 h for the non-IINB group. Differences were significant at 1 h, 12 h, 24 h, and 48 h (p<0.05). Mean postoperative hospital stay was 5.7 days in the IINB group and 6.5 days in the non-IINB group (p<0.05).IINB associated with mini-thoracotomy reduces postoperative pain and contributes to improve postoperative outcome after major pulmonary resections.