Mortality rate and risk factors for gastrointestinal bleeding in elderly patients
Registrie
Male
Logistic Model
Anemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity;
610
Severity of Illness Index
Anemia, Anticoagulant, Antiplatelet drug, Diverticulosis, Gastric ulcer, Multimorbidity
03 medical and health sciences
0302 clinical medicine
Risk Factors
616
80 and over
Humans
Anemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Aged; Aged, 80 and over; Female; Gastrointestinal Hemorrhage; Hospital Mortality; Humans; Italy; Length of Stay; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Severity of Illness Index; Multimorbidity
Hospital Mortality
Prospective Studies
Registries
Multivariate Analysi
anemia; anticoagulant; antiplatelet drug; diverticulosis; gastric ulcer; multimorbidity; aged; aged, 80 and over; female; gastrointestinal hemorrhage; hospital mortality; humans; italy; length of stay; logistic models; male; multivariate analysis; platelet aggregation inhibitors; prospective studies; registries; risk factors; severity of illness index; multimorbidity
Aged
Diverticulosis
Aged, 80 and over
Diverticulosi
Platelet Aggregation Inhibitor
Risk Factor
Gastric ulcer
Anemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity
Anticoagulant
Multimorbidity
Anemia
Anemia, Anticoagulant, Antiplatelet drug, Diverticulosis, Gastric ulcer, Multimorbidity, Aged, Aged, 80 and over, Female, Gastrointestinal Hemorrhage, Hospital Mortality, Humans, Italy, Length of Stay, Logistic Models, Male, Multivariate Analysis, Platelet Aggregation Inhibitors, Prospective Studies, Registries, Risk Factors, Severity of Illness Index, Multimorbidity
anemia; anticoagulant; antiplatelet drug; diverticulosis; gastric ulcer; multimorbidity; aged; aged 80 and over; female; gastrointestinal hemorrhage; hospital mortality; humans; italy; length of stay; logistic models; male; multivariate analysis; platelet aggregation inhibitors; prospective studies; registries; risk factors; severity of illness index; multimorbidity
Length of Stay
Anemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Internal Medicine
3. Good health
Prospective Studie
Logistic Models
Italy
Multivariate Analysis
Anemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Aged; Aged; 80 and over; Female; Gastrointestinal Hemorrhage; Hospital Mortality; Humans; Italy; Length of Stay; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Severity of Illness Index; Multimorbidity
Female
Gastrointestinal Hemorrhage
Antiplatelet drug
Platelet Aggregation Inhibitors
Human
DOI:
10.1016/j.ejim.2018.11.003
Publication Date:
2018-12-04T01:41:02Z
AUTHORS (12)
ABSTRACT
Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients.Since 2008, samples of elderly patients (age ≥ 65 years) with multimorbidity admitted to 101 internal medicine wards across Italy have been prospectively enrolled and followed-up (REPOSI registry). Diagnoses of GIB, length of stay (LOS), mortality rate, and possible risk factors, including drugs, index of comorbidity (Cumulative Illness Rating Scale [CIRS]), polypharmacy, and chronic diseases were assessed. Adjusted multivariate logistic regression models were computed.3872 patients were included (mean age 79 ± 7.5 years, F:M ratio 1.1:1). GIB was reported in 120 patients (mean age 79.6 ± 7.3 years, F:M 0.9:1), with a crude prevalence of 3.1%. Upper GIB occurred in 72 patients (mean age 79.3 ± 7.6 years, F:M 0.8:1), lower GIB in 51 patients (mean age 79.4 ± 7.1 years, F:M 0.9:1), and both upper/lower GIB in 3 patients. Hemorrhagic gastritis/duodenitis and colonic diverticular disease were the most common causes. The LOS of patients with GIB was 11.7 ± 8.1 days, with a 3.3% in-hospital and a 9.4% 3-month mortality rates. Liver cirrhosis (OR 5.64; CI 2.51-12.65), non-ASA antiplatelet agents (OR 2.70; CI 1.23-5.90), and CIRS index of comorbidity >3 (OR 2.41; CI 1.16-4.98) were associated with GIB (p < 0.05).A high index of comorbidity is associated with high odds of GIB in elderly patients. The use of non-ASA antiplatelet agents should be discussed in patients with multimorbidity.
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CITATIONS (63)
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