The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

• DOI: 10.1016/j.ejmech.2004.10.011
• Publication Date: 2005-01-05T12:28:33Z
• Authors: Derek Sharples; Gabriella Spengler; Joseph Molnár; Zsuzsanna Antal; Annamária Molnár; János T. Kiss; József A. Szabó; Andreas Hilgeroth; Sandrine Gallo; Abdallah Mahamoud; Jacques Barbe
• Keywords: Fluorenes; Aza-fluorenes; Dose-Response Relationship, Drug; Molecular Structure; Antineoplastic Agents; MDR1 p-glycoprotein; DNA; Transfer RNA interaction; Pregnanes; DNA interaction; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; RNA, Transfer; Drug Resistance, Neoplasm; Pyridoquinolines; Cell Line, Tumor; Quinolines; Humans; Drug Interactions; ATP Binding Cassette Transporter, Subfamily B, Member 1; Genes, MDR; Plasmids

Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers.