Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51)

• DOI: 10.1016/j.ejmech.2007.01.006
• Publication Date: 2007-01-25T15:04:55Z
• Authors: Qing-Yan Sun; Jian-Ming Xu; Yong-Bing Cao; Wan-Nian Zhang; Qiu-Ye Wu; Da-Zhi Zhang; Jun Zhang; Hui-Qing Zhao; Yuan-Ying Jiang
• Keywords: Spectrometry, Mass, Electrospray Ionization; Antifungal Agents; Magnetic Resonance Spectroscopy; Cytochrome P-450 Enzyme System; Spectrophotometry, Infrared; Microbial Sensitivity Tests; Enzyme Inhibitors; Triazoles; 01 natural sciences; 3. Good health; 0104 chemical sciences

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols have been designed and synthesized on the basis of the structure-activity relationships and antimycotic mechanism of azole antifungal agents. Their structures were confirmed by elemental analysis, IR, MS and (1)H NMR. Results of preliminary antifungal tests against eight human pathogenic fungi (Candida albicans, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, Fonsecaea compacta, and Microsporum gypseum) in vitro showed that all title compounds exhibited activity against fungi tested to some extent. Among the compounds tested, all compounds showed higher activity against C. albicans than fluconazole in vitro. Compounds 3, 6-8, 28, 29, and 32 exhibited the same activities against C. albicans as voriconazole (with the MIC value of 0.0152microg/mL). Compounds 3, 6, and 7 showed higher activity against C. parapsilosis than all five positive controls.