Synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines

• DOI: 10.1016/j.ejmech.2010.11.039
• Publication Date: 2010-12-02T09:37:49Z
• Authors: Natarajan Arumugam; Govindasami Periy...; Raghavachary Ragh...; Subban Kamalraj; Johnpaul Muthumary
• Keywords: Models, Molecular; 0301 basic medicine; Staphylococcus aureus; Pyrrolidines; Molecular Conformation; Stereoisomerism; Microbial Sensitivity Tests; Salmonella typhi; Crystallography, X-Ray; beta-Lactams; 01 natural sciences; Anti-Bacterial Agents; 0104 chemical sciences; Structure-Activity Relationship; 03 medical and health sciences; Proteus vulgaris; Spiro Compounds; Proteus mirabilis; Pyrrolizidine Alkaloids

AbstractA facile synthesis of novel β‐lactam substituted spiropyrrolidines and ‐pyrrolizidines is described.