Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

• DOI: 10.1016/j.ejmech.2011.03.065
• Publication Date: 2011-04-25T01:52:45Z
• Authors: Stefanie Schmidt; Lutz Preu; Thomas Lemcke; Frank Totzke; Christoph Schächtele; Michael H.G. Kubb...; Conrad Kunick
• Keywords: Cancer cell lines; Structure–activity relationship

AbstractBenzoic acid hydrazides (III) and (VI) are reacted with indolyloxoacetyl chloride (IV) to afford N,N′‐diacylated hydrazides (V) and (VII).