Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFα-induced nuclear factor-κB activation inhibition

• DOI: 10.1016/j.ejmech.2012.02.023
• Publication Date: 2012-02-17T13:16:03Z
• Authors: Yinglin Zuo; Yi Yu; Shuni Wang; Weiyan Shao; Binhua Zhou; Li Lin; Zhuoyu Luo; Ruogu Huang; Jun Du; Xianzhang Bu
• Keywords: Chalcone; Sulforhodamine B; Knoevenagel condensation; Viability assay; Suzuki reaction

AbstractA variety of biaryl‐based chalcones are designed, synthesized and evaluated for their inhibitory activities against five cancer cell lines.