Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases

• DOI: 10.1016/j.ejmech.2012.02.050
• Publication Date: 2012-03-05T23:42:45Z
• Authors: Edita Čapkauskaitė; Asta Zubrienė; Lina Baranauskienė; Giedrė Tamulaitienė; Elena Manakova; Visvaldas Kairys; Saulius Gražulis; Sigitas Tumkevičius; Daumantas Matulis
• Keywords: Isothermal Titration Calorimetry; Affinities; Carbonic anhydrase II; Docking (animal); Binding affinities

AbstractS‐Alkylation of pyrimidine derivatives (I) with ω‐bromoacetylbenzenesulfonamides (II) and (IV) affords the title compounds (III) and (V), respectively.