Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives

• DOI: 10.1016/j.ejmech.2012.04.014
• Publication Date: 2012-04-27T06:30:26Z
• Authors: M.M. Shulaeva; S.G. Fattakhov; L.F. Saifina; R.V. Chestnova; R.Sh. Valijev; D.N. Mingaleev; A.D. Voloshina; V.S. Reznik
• Keywords: Triazines; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Amides; 01 natural sciences; Anti-Bacterial Agents; Rats; 0104 chemical sciences; 3. Good health; Mice; Structure-Activity Relationship; Animals; Sulfonic Acids

A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.