Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-l-amino acid dianion

• DOI: 10.1016/j.ejmech.2012.09.052
• Publication Date: 2012-10-23T19:31:23Z
• Authors: Jinchao Zhang; Lili Ma; Huiru Lu; Yuechai Wang; Shenghui Li; Shuxiang Wang; Guoqiang Zhou
• Keywords: Anions; Models, Molecular; Dose-Response Relationship, Drug; Molecular Structure; Antineoplastic Agents; HL-60 Cells; Diamines; 01 natural sciences; 0104 chemical sciences; Tosyl Compounds; Structure-Activity Relationship; Cell Line, Tumor; Organometallic Compounds; Humans; Amino Acids; Drug Screening Assays, Antitumor; Palladium; Cell Proliferation; Platinum

Eight novel platinum(II)/palladium(II) complexes with 1,3-dap and 4-toluensulfonyl-l-amino acid dianion, [Pt(1,3-dap)(TsalaNO)]·0.5H(2)O (1a), [Pt(1,3-dap)(TsvalNO)] (1b), [Pt(1,3-dap)(TspheNO)] (1c), [Pt(1,3-dap)(TsserNO)] (1d), [Pd(1,3-dap)(TsalaNO)]·1.5H(2)O (2a), [Pd(1,3-dap)(TsvalNO)] (2b), [Pd(1,3-dap)(TspheNO)] (2c) and [Pd(1,3-dap)(TsileNO)] (2d) have been synthesized and characterized by elemental analysis, IR, UV, (1)H NMR and mass spectrometry techniques. Crystal structure of the complex 1b has been determined by X-ray diffraction. The cytotoxicity was tested by MTT and SRB assays. The complexes (1a-1d and 2a-2d) exert cytotoxicity against Bel-7402, HL-60, KB and BGC-823, but none of them is more active than cisplatin. The results suggest that metal ions, amino acids and aliphatic N-containing ligands have effect on cytotoxicity, while the IC(50) values do not show definite correlation with variation of them.