Recent developments of coumarin-containing derivatives and their anti-tubercular activity

• DOI: 10.1016/j.ejmech.2017.05.004
• Publication Date: 2017-05-02T19:02:24Z
• Authors: Yuan-Qiang Hu; Zhi Xu; Shu Zhang; Xiang Wu; Jun-Wei Ding; Zao-Sheng Lv; Lian-Shun Feng
• Keywords: 0301 basic medicine; Structure-Activity Relationship; 03 medical and health sciences; Molecular Structure; Coumarins; Drug Design; Antitubercular Agents; Tuberculosis; Microbial Sensitivity Tests; Mycobacterium tuberculosis; 3. Good health

Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs (pulmonary TB) apart from other vital organs. The emergence of drug-resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and the recently cases of totally drug resistant (TDR) towards currently accessible standard drugs was increased up to alarming level in the recent decades. In pursuit of searching new anti-TB agents, numerous of derivatives have been synthesized and screened for their anti-TB activity. Coumarins are one of the most important classes of natural products that exhibited various biological activities, and their derivatives regarded as a new class of effective anti-TB candidates owing to their potential anti-TB activity. Thus, coumarin skeleton has attracted great interest in the development of new anti-TB agents. This review outlines the advances in the application of coumarin-containing derivatives as anti-TB agents and the critical aspects of design and structure-activity relationship of these derivatives.