Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA

• DOI: 10.1016/j.ejmp.2022.11.012
• Publication Date: 2022-12-20T10:01:31Z
• Authors: Dousatsu Sakata; Ryoichi Hirayama; Wook-Geun Shin; Mauro Belli; Maria A. Tabocchini; Robert D. Stewart; Oleg Belov; Mario A. Bernal; Marie-Claude Bordage; Jeremy M.C. Brown; Milos Dordevic; Dimitris Emfietzo...; Ziad Francis; Susanna Guatelli; Taku Inaniwa; Vladimir Ivanchenko; Mathieu Karamitros; Ioanna Kyriakou; Nathanael Lampe; Zhuxin Li; Sylvain Meylan; Claire Michelet; Petteri Nieminen; Yann Perrot; Ivan Petrovic; Jose Ramos-Mendez; Aleksandra Ristic...; Giovanni Santin; Jan Schuemann; Hoang N. Tran; Carmen Villagrasa; Sebastien Incerti
• Keywords: 0301 basic medicine; 570; Geant4-DNA; Cell Survival; 612; DNA; simulation; Cell survival; Kinetics; 03 medical and health sciences; 0302 clinical medicine; Cricetinae; [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]; DNA damage; Animals; Protons; Monte Carlo; Monte Carlo Method; Monte Carlo simulation; DNA Damage

Purpose:Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim present study is to extend a Geant4-DNA radiobiological application by incorporating feature allowing for prediction rejoining kinetics and corresponding cell surviving fraction along time after irradiation, Chinese hamster V79 line, which one most popular widely investigated lines radiobiology.Methods:We implemented Two-Lesion Kinetics (TLK) model, originally proposed Stewart, allows simulations calculate residual damage via number its complexity as inputs.Results:By optimizing model parameters TLK accordance experimental data on V79, we were able predict both at low linear energy transfers (LET) fraction.Conclusion:This first demonstrate implementation with estimated damage, realistic geometrical simulated full track MC level various LET. These simulation make link between mechanistic physical/chemical processes these two specific biological endpoints.