Preeclampsia and HIV infection

• DOI: 10.1016/j.ejogrb.2004.04.014
• Publication Date: 2004-10-28T18:44:17Z
• Authors: Rosiane Mattar; Abes M. Amed; Prescilla C. Lindsey; Nelson Sass; Silvia Daher
• Keywords: Etiology; Endothelial Dysfunction; Immune Dysregulation

Preeclampsia is a common complication of pregnancy and a major cause of maternal morbidity. It is associated with placental disorder endothelial cell dysfunction and systemic vasospasm. The events leading these alterations remains unclear but it seems that abnormal activation of the immune system play a relevant role in the etiology of preeclampsia. Some reports suggest a trend toward an increasing prevalence of human immunodeficiency virus (HIV) infection in pregnancy. Different studies have evaluated maternal immune response to HIV infection in pregnancy and investigated whether its represents a risk factor for adverse perinatal outcome however controversial results have been obtained. Our purpose was to investigate the rate of preeclampsia in HIV seropositive pregnant women that were referred to Obstetric Outpatient Clinic of UNIFESP-EPM between 2000 and 2002. (excerpt)