Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology

• DOI: 10.1016/j.ejpb.2023.11.023
• Publication Date: 2023-12-02T23:45:59Z
• Authors: Evelyn Ochoa; Lucia Morelli; Lucia Salvioni; Marco Giustra; Beatrice De Santes; Francesca Spena; Linda Barbieri; Stefania Garbujo; Matteo Viganò; Brian Novati; Giulia Tomaino; Saliha Moutaharrik; Davide Prosperi; Luca Palugan; Miriam Colombo
• Keywords: Excipients; 3D printing; Binder jetting; Co-processed excipients; Orally disintegrating tablets;; Drug Compounding; Printing, Three-Dimensional; Materials Testing; Administration, Oral; Tablets

The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation their potential ODT 3D printing technology remains almost unexplored. present study aimed to estimate commercially available excipients, conventionally applied in protocols, ODTs with binder jetting-3D technology. latter was selected among techniques because deposition multiple powder layers allows obtaining highly porous and easily disintegrating dosage forms. influence some process parameters, including layer thickness, type waveform spread speed, on physical mechanical properties prototypes printed were evaluated. Our results suggested that could benefit from excipients solid optimization conducted experiments reported this work indicated additional needed improve resulting ODTs.