Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol

• DOI: 10.1016/j.ejphar.2005.07.002
• Publication Date: 2005-08-16T07:12:51Z
• Authors: Kenji Hashimoto; Yuko Fujita; Eiji Shimizu; Masaomi Iyo
• Keywords: Male; Analysis of Variance; Mice, Inbred ICR; Time Factors; Behavior, Animal; Phencyclidine; Mice; 03 medical and health sciences; 0302 clinical medicine; Exploratory Behavior; Hallucinogens; Animals; Haloperidol; Cognition Disorders; Clozapine; Antipsychotic Agents

This study was undertaken to examine the effects of subsequent administration of antipsychotic drugs (clozapine and haloperidol) on cognitive deficits in mice after repeated administration of phencyclidine (PCP). In the novel object recognition test, repeated administration of PCP (10 mg/kg) significantly decreased exploratory preference in the retention test session but not in the training test session. PCP-induced deficits were significantly improved by subsequent subchronic (2 weeks) administration of clozapine (5 mg/kg), but not haloperidol (0.1 mg/kg). These findings suggest that PCP-induced cognitive deficits using the novel object recognition test may be a potential animal model of atypical antipsychotic activity.