SFN promotes renal fibrosis via binding with MYH9 in chronic kidney disease

• DOI: 10.1016/j.ejphar.2024.176806
• Publication Date: 2024-07-09T00:06:18Z
• Authors: Fang Wang; Xiao-guo Suo; Jia-nan Wang; Cheng-yi Liu; Cheng-cheng Liu; Cong Wang; Jing Li; Zi-hao Duan; Feng-sen Zhang; Yi-miao Xia; Jun-jie Jiang; Yun-wu Hao; Guang-yuan Li; Xiao-ming Meng; Yun-xia Shao; Fa-cai Wang
• Keywords: Nephrology

Chronic kidney disease (CKD) is a clinical syndrome characterized by persistent renal function decline. Renal fibrosis the main pathological process in CKD, but an effective treatment does not exist. Stratifin (SFN) highly-conserved, multi-function soluble acidic protein. Therefore, this study explored effects of SFN on fibrosis. First, we found that was highly expressed patients with as well animal and cell models. Next, transforming growth factor-beta 1 (TGF-β