SFN promotes renal fibrosis via binding with MYH9 in chronic kidney disease

Nephrology
DOI: 10.1016/j.ejphar.2024.176806 Publication Date: 2024-07-09T00:06:18Z
ABSTRACT
Chronic kidney disease (CKD) is a clinical syndrome characterized by persistent renal function decline. Renal fibrosis the main pathological process in CKD, but an effective treatment does not exist. Stratifin (SFN) highly-conserved, multi-function soluble acidic protein. Therefore, this study explored effects of SFN on fibrosis. First, we found that was highly expressed patients with as well animal and cell models. Next, transforming growth factor-beta 1 (TGF-β
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