Vitexin promotes the anti-senescence effect via inhibiting JAK2/STAT3 in D-Galactose-induced progeria mice and stress-induced premature senescence

• DOI: 10.1016/j.ejphar.2024.176865
• Publication Date: 2024-07-30T01:46:27Z
• Authors: Xiaojuan Han; Lu Li; Jiamei Xie; Qing Lei; Yansong Li; Huan Liu; Haoran Sun; Xiaohua Zhang; Xingchun Gou
• Keywords: Progeria; Senescence; Premature aging

Vitexin is a natural flavonoid glycoside compound extracted from the leaves and seeds of Vitex negundo. It widely distributed in stems numerous plants exhibites remarkable anti-tumor, anti-inflammatory, anti-hypertensive properties. However, whether vitexin presents anti-aging senescence prevention effect has not been fully elucidated. The purpose this study to investigate on progeria mice cellular senescence, as well its underlying molecular mechanisms. To generate premature aging/senescence model vivo vitro, we used D-galactose (D-gal), hydrogen peroxide (H