Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro

• DOI: 10.1016/j.ejps.2004.04.011
• Publication Date: 2004-10-14T15:19:00Z
• Authors: Hitoe Takahashi; Atsuyoshi Nishina; Hirokazu Kimura; Kenji Motoki; Mamoru Koketsu; Hideharu Ishihara
• Keywords: 0301 basic medicine; Structure-Activity Relationship; 03 medical and health sciences; Superoxides; Organoselenium Compounds; Luminescent Measurements; Free Radical Scavengers; Amides

We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O(2)(-). N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC(50) of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals.