Dissolution changes in drug-amino acid/biotin co-amorphous systems: Decreased/increased dissolution during storage without recrystallization

• DOI: 10.1016/j.ejps.2023.106526
• Publication Date: 2023-07-12T01:13:43Z
• Authors: Zhiren Zou; Qiang Huang; Xiaobo Li; Xianzhi Liu; Lina Yin; Yunjie Zhao; Guang Liang; Wenqi Wu
• Keywords: Recrystallization (geology)

Co-amorphous systems have been proven to be a promising strategy address the poor water solubility of poorly water-soluble drugs. Generally, initial dissolution behaviors after co-amorphous system preparation and potential recrystallization during storage are used evaluate performance systems. However, this study reveals that decreased unexpected increased were observed though maintained amorphous form. Three drugs (valsartan, tadalafil, mebendazole) three co-formers (arginine, tryptophan, biotin) prepare samples stored for different times. After 80 d, most form, however, intrinsic rates (IDRs) both in these non-recrystallized The moisture changes possible drug-co-former molecular interactions showed no effect on changes, while phase separation might play role it. In conclusion, more attention should paid storage. Focusing sample physical is not enough development future.