Assessment of fracture risk in a cohort of Egyptian female Systemic Lupus erythematosus patients

• DOI: 10.1016/j.ejr.2017.07.006
• Publication Date: 2017-08-01T23:01:05Z
• Authors: Eman A. Hafez; Samah A. ElBakry; Shafica I. Ibrahim; Caroline S. Morad; Sarah A. Hamza; Dina M. Abd El-Kh...
• Keywords: FRAX; Osteopenia

To assess the fracture risk in a cohort of Egyptian systemic lupus erythematosus (SLE) females correlation to some disease variables. Seventy female SLE patients ≥40 years old were enrolled with detailed history taking, assessment activity and damage index. Measurement Serum calcium, phosphorus alkaline phosphatase, bone mineral density (BMD) by dual emission X-ray absorptiometry (DEXA) at lumbar spine (LS) femoral neck (FN), serum osteocalcin level World Health Organization (WHO) tool (FRAX®). 20% had LS osteoporosis, 35.7% osteopenia, 8.6% FN 42.9% osteopenia. Ten-year major hip fractures was high evidenced FRAX-Major ≥20% 10% patients, FRAX-Hip ≥3% 27.1% patients. significantly decreased lower BMD than those normal BMD, osteoporosis A significant negative found between age duration, index scores, current intravenous pulse cumulative steroids, immunosuppressants, anticoagulants, but there positive antimalarials calcium supplements. Increasing age, anti-DNA titres, higher associated risk. FRAX predicted among low mass not just frank osteoporosis. Physicians should be alerted future for periodic monitoring.