Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients

• DOI: 10.1016/j.ekir.2023.08.021
• Publication Date: 2023-08-24T00:05:45Z
• Authors: Mathilde Colladant; Melchior Chabannes; Thomas Crepin; Jamal Bamoulid; Cécile Courivaud; Didier Ducloux
• Keywords: Quartile; Univariate analysis

Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact insulin resistance on CV after transplantation is not well defined.We tested whether triglyceride-glucose (TyG) index, a surrogate marker resistance, may predict posttransplant CVEs in cohort 715 consecutive KTRs all included 1 year transplant.Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion 4.75 0.29 (median, 4.73 [4.14-5.84]). In multiple regression analysis, having above median value associated higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total 127 (17.7%) occurred during study period. univariate strongly CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42-3.50, for each increase 0.1 TyG, P < 0.001). best predictive 4.87 (HR 6.32, 3.30-12.11, gradually (quartile 2, HR 1.71, 0.84-5.20, = 0.139; quartile 3, 3.12, 1.61-6.02, 0.001; 4, 7.46, 4.03-13.80, 0.001, vs. 1). remained multivariate analysis 2.11, 1.22-3.68, 0.001).Insulin as measured by KTRs. Improving sensitivity seems to be major issue prevent morbidity mortality this high-risk