WCN24-1213 THE ROLE OF OXYSTEROL-BINDING PROTEIN LIKE 7 IN PODOCYTE HEALTH: IMPLICATIONS IN CHRONIC KIDNEY DISEASE PATHOPHYSIOLOGY

• DOI: 10.1016/j.ekir.2024.02.243
• Publication Date: 2024-04-03T09:56:40Z
• Authors: Jeffrey Pressly; Joanne Duara; Janina Mueller-Deile; Mario Schiffer; Sandra Merscher; Alessia Fornoni
• Keywords: Pathophysiology

Oxysterol-binding proteins (OSBPs) are known for their multifaceted roles, including the transfer of cholesterol between endoplasmic reticulum and Golgi apparatus, as well regulating efflux. Recent evidence suggests that deficiency one specific OSBP, OSBPL7, can attenuate autophagic processes in various cell types, thereby potentially influencing lipid trafficking functionality podocytes—key cells involved renal filtration. Given these preliminary observations, current study aims to elucidate role OSBPL7 pathophysiology chronic kidney disease (CKD).