Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice

• DOI: 10.1016/j.eng.2021.08.019
• Publication Date: 2021-10-27T00:44:40Z
• Authors: Pan Diao; Fangping Jia; Xiaojing Wang; Xiao Hu; Takefumi Kimura; Takero Nakajima; Toshifumi Aoyama; Kyoji Moriya; Kazuhiko Koike; Naoki Tanaka
• Keywords: Steatosis; Hepatitis C

Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) worldwide. Among the structural proteins HCV, HCV core protein has ability to regulate gene transcription, lipid metabolism, cell proliferation, apoptosis, autophagy, all which are closely related development HCC. Transgenic mice carrying exhibited age-dependent insulin resistance, hepatic steatosis, HCC that resembled clinical characteristics hepatitis patients. Several dietary modifications, including calorie restriction diets rich in saturated fatty acids, trans or cholesterol, were found influence steatogenesis tumorigenesis transgenic mice. These strategies modulated stress addition fibrotic processes microenvironment, thereby corroborating close interconnection between habits steatosis-related hepatocarcinogenesis. In this review, we summarize findings obtained from mouse models for genome, with special focus on mice, discuss mechanisms hepatocarcinogenesis induced by impact steatosis-derived development.