Genomic Epidemiology of ST34 Monophasic Salmonella enterica Serovar Typhimurium from Clinical Patients from 2008 to 2017 in Henan, China

• DOI: 10.1016/j.eng.2022.05.006
• Publication Date: 2022-05-29T13:35:16Z
• Authors: Yujiao Mu; Ruichao Li; Pengcheng Du; Pei Zhang; Yan Li; Shenghui Cui; Séamus Fanning; Li Bai
• Keywords: Salmonella enterica; Genomic island; Molecular Epidemiology

Salmonella enterica serovar 4,[5],12:i:- (S. 4,[5],12:i:-) is a monophasic variant of Typhimurium that has emerged as global causing public health concern. To date, the epidemiology and genomic characterization this pathogen in China have not been well described. We investigated prevalence, antimicrobial resistance (AMR) phenotypes, population genomics sequence type 34 (ST34) S. among cases human salmonellosis Henan Province, China. A total 100 ST34 isolates were studied from 2008 to 2017 found mostly resistant ampicillin (AMP), streptomycin (STR), sulfonamides (SUL), tetracycline (TET) (ASSuT). Bayesian phylogenetic analysis demonstrated identified related European lineage evolved into two major clades with different genes plasmid profiles. Notably, clade 1 showed significantly higher rate mutations gyrA plasmid-mediated quinolone genes. The carrying resistance-containing region (encoding R-type ASSuT), including blaTEM-1B (conferring AMP), strAB sul2 tet(B) inserted fljBA operon, was responsible for most variants 2. IncHI2 plasmids dominant multi-drug mobile genetic elements accounting transmission acquired serovar, these more prevalent 1. Our findings highlighted increasing prevalence China, along differential characteristics gene acquisition various lineages. Based on our data, control measures are required address spread zoonotic pathogen. Further owing its potential origin food-producing animals, "One Health" approach, should be implemented support surveillance whilst informing interventional strategies.